Table 2 Phenotypic characteristics of pathophysiological small animal models
| Species | Modell | Strain | Age (wks) | HW (mg) | BW (g) | HW/ BW-ratio | Blood Glucose (mg/dl) | Other |
|---|---|---|---|---|---|---|---|---|
| Mouse | Ctrl | Ncor1tm1Anh/J | 20 | 150.5 ± 10.1 (n = 4) | 33.1 ± 2.3 | 4.46 ± 0.1 (n = 4) | 163 ± 15 | – |
| Type I DM | Ncor1tm1Anh/J | 20 | 141.5 ± 17.7 (n = 2) | 28.3 ± 2.6 | 5.34 ± 0.2 (n = 2) | 537 ± 101 | – | |
| Ctrl | db/db+ | 20 | 158.2 ± 2.6 | 32.2 ± 0.6 | 4.92 ± 0.1 | 146 ± 23.9 | – | |
| Type II DM | db+/db+ | 20 | 124.8 ± 1.9 | 30.4 ± 1.7 | 3.88 ± 0.2 | 514 ± 68.6 | – | |
| Ctrl | 129/Sv | 8–10 | 113.7 ± 2.8a | 26.8 ± 1.7a | 4.24 ± 0.1a | 156 ± 8a | – | |
| Iso | 129/Sv | 8–10 | 109.3 ± 2.6a | 26.6 ± 1.8a | 4.11 ± 0.1a | 145 ± 6a | – | |
| Ctrl | C57BL/6J | 18–19 | 123.0 ± 8.3 | 28.0 ± 0.3 | 4.40 ± 0.1 | 192.7 | Gradient Pb | |
| ±24.7 | −2.17 ± 1.1 | |||||||
| TAC | C57BL/6J | 18–19 | 160.3 ± 29.1 | 28.9 ± 0.3 | 5.72 ± 0.3 | 192.2 | Gradient Pb | |
| ±40.6 | 32.22 ± 3.2 | |||||||
| Rats | Ctrl | tetO-shIR | 18 | – | 427 ± 6.8 | – | 108.5 ± 1.5 | – |
| TetO | tetO-shIR | 26 | – | 404 ± 5.3 | – | 427.5 ± 23 | – | |
| mRen | mRen27 | 26 | – | 438 ± 12.7 | – | 117 ± 2.5 | – | |
| TetO/mRen | mRen27/tetO-shIR | 26 | – | 345 ± 12.9 | – | 309 ± 25.1 | – | |
| Ctrl | Sprague Dawley | 7 | – | 180 ± 7.4 | – | – | – | |
| dTGR | female:TGR(hRen)L10 J | 7 | – | 170 ± 2.8 | – | – | – | |
|
male:TGR(hAogen)L162 3 |